Accretropin Medical Drug

Medical Drugs > Other

Description

Accretropin (recombinant human growth hormone (r-hGH); somatropin) is a protein produced by recombinant DNA technology. It is produced during fermentation in E. coli yielding a protein containing 192 amino acids. The N-terminal amino acid, methionine, is later removed to yield a protein that is chemically and physicochemically identical to pituitary derived human growth hormone, consisting of 191 amino acids in a single polypeptide chain.

Accretropin is distributed in a liquid solution containing 1 mL of a 5 mg/mL solution of growth hormone (15 IU/mL). The formulation also contains 0.75% NaCl, 0.34% Phenol (as preservative), 0.2% Pluronic F-68 (a non-ionic surfactant) and is designed for subcutaneous administration. Accretropin is stabilized to pH 6.0 with 10 mM NaPO4 buffer.

Accretropin (somatropin) is indicated for:

* treatment of pediatric patients who have growth failure due to an inadequate secretion of normal endogenous growth hormone.

* treatment of short stature associated with Turner Syndrome in pediatric patients whose epiphyses are not closed.